Handheld dual-axis confocal microscopy for neurosurgical guidance: Developing a 2nd-generation prototype

Kevin W. Bishop; Bingwen Hu; Adam K. Glaser; Nader Sanai M.D.; Jonathan T. C. Liu

doi:10.1117/12.2647997

17 March 2023 Handheld dual-axis confocal microscopy for neurosurgical guidance: Developing a 2nd-generation prototype

Kevin W. Bishop, Bingwen Hu, Adam K. Glaser, Nader Sanai M.D., Jonathan T. C. Liu

Proceedings Volume PC12356, Endoscopic Microscopy XVIII; PC1235607 (2023) https://doi.org/10.1117/12.2647997
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The recent FDA approval of 5-aminolevulinic acid (5-ALA)/protoporphyrin IX (PpIX) for fluorescence-guided resection of gliomas has significantly improved surgeons’ ability to identify and remove bulk high-grade tumors using widefield imaging. However, the limited sensitivity of widefield fluorescence imaging makes it challenging to identify regions of sparse and low fluorophore accumulation, such as in low-grade gliomas and at the diffuse margins of all gliomas. Here we describe several improvements on a handheld confocal microscope designed to detect sparse PpIX fluorescence in vivo, with the goal of providing a quantitative method to guide glioma resections.

Conference Presentation

Citation Download Citation

Kevin W. Bishop, Bingwen Hu, Adam K. Glaser, Nader Sanai M.D., and Jonathan T. C. Liu "Handheld dual-axis confocal microscopy for neurosurgical guidance: Developing a 2nd-generation prototype", Proc. SPIE PC12356, Endoscopic Microscopy XVIII, PC1235607 (17 March 2023); https://doi.org/10.1117/12.2647997

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Confocal microscopy

Surgery

Prototyping

In vivo imaging

Signal detection

Luminescence

Tumors

Show All Keywords

Keywords/Phrases

Search In:

Publication Years