Three-dimensional imaging of the enteric nervous system for the design of a multimodal optogenetic endomicroscope

Arielle Planchette; Jules Scholler; Yoseline Rosales Cabara; Ivana Gantar; Michalina Gora

doi:10.1117/12.2649380

17 March 2023 Three-dimensional imaging of the enteric nervous system for the design of a multimodal optogenetic endomicroscope

Arielle Planchette, Jules Scholler, Yoseline Rosales Cabara, Ivana Gantar, Michalina Gora

Author Affiliations +

Proceedings Volume PC12356, Endoscopic Microscopy XVIII; PC123560L (2023) https://doi.org/10.1117/12.2649380
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Many neurological and digestive diseases have been linked to dysfunctions of the Enteric Nervous System (ENS) or gut microbiome imbalances. However, to this day, no tool allows a comprehensive in-vivo interrogation of the ENS. To address this lack of such technology, we performed a complete characterization and monitoring of the ENS to design an optogenetic endomicroscope based on Optical Coherence Tomography, capable of in-vivo mapping the ENS's morphology and functionality as well as in-situ microbiota sampling. We anticipate that researchers and clinicians would benefit from such a device to gain new insights into the microbiota-gut-brain axis and improve standards of care.

Conference Presentation

Citation Download Citation

Arielle Planchette, Jules Scholler, Yoseline Rosales Cabara, Ivana Gantar, and Michalina Gora "Three-dimensional imaging of the enteric nervous system for the design of a multimodal optogenetic endomicroscope ", Proc. SPIE PC12356, Endoscopic Microscopy XVIII, PC123560L (17 March 2023); https://doi.org/10.1117/12.2649380

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