Early prediction of neoadjuvant chemotherapy outcome with longitudinal breast diffuse optical tomography

Bin Deng; Ailis Muldoon; Jayne Cormier; Mansi A. Saksena; Steven J. Isakoff; Stefan A. Carp

doi:10.1117/12.2650855

7 March 2023 Early prediction of neoadjuvant chemotherapy outcome with longitudinal breast diffuse optical tomography

Bin Deng, Ailis Muldoon, Jayne Cormier, Mansi A. Saksena, Steven J. Isakoff, Stefan A. Carp

Proceedings Volume PC12376, Optical Tomography and Spectroscopy of Tissue XV; PC123760J (2023) https://doi.org/10.1117/12.2650855
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Multimodal x-ray mammography and optical imaging data were acquired on six breast cancer patients who underwent neoadjuvant chemotherapy (NACT) but reponded differently to their treatment. Changes in tumor contrast quantified by total hemoglobin concentration (HbT) between baseline and pre-cycle 3 are distinctive across various levels of pathological outcomes. While decreases in lesion size have been observed in all cases regardless of pathological outcomes, optical contrast shows more distinctive response characteristics that could potentially be used to differentiate complete responders from partial responders.

Conference Presentation

Citation Download Citation

Bin Deng, Ailis Muldoon, Jayne Cormier, Mansi A. Saksena, Steven J. Isakoff, and Stefan A. Carp "Early prediction of neoadjuvant chemotherapy outcome with longitudinal breast diffuse optical tomography", Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC123760J (7 March 2023); https://doi.org/10.1117/12.2650855

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