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16 March 2023 Early diagnosis of cancer from liquid biopsies via Raman spectroscopy combined with decision algorithms (Conference Presentation)
Elisa Grassi, Jean-Marc Nabholz, Roberto Incitti, Khalid Al-Saleh, Mohun Bahadoor, Takashi Gojobori, Carlo Liberale
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Proceedings Volume PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; PC123910R (2023) https://doi.org/10.1117/12.2650612
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Current methods for cancer screening are invasive and not accurate in the early stages of the disease. A revolutionary development in the diagnosis of cancer is the analysis of liquid biopsies via Raman spectroscopy. We propose a method for the screening and prognosis of cancer combining Raman spectroscopy with decision algorithms. We tested the efficiency of our method probing the spectra of blood plasma samples from cancer patients and healthy controls, proceeding with a Support Vector Machine classification and a leave-one out cross-validation, obtaining sensitivity and specificity results higher than 90%.
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Elisa Grassi, Jean-Marc Nabholz, Roberto Incitti, Khalid Al-Saleh, Mohun Bahadoor, Takashi Gojobori, and Carlo Liberale "Early diagnosis of cancer from liquid biopsies via Raman spectroscopy combined with decision algorithms (Conference Presentation)", Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910R (16 March 2023); https://doi.org/10.1117/12.2650612
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KEYWORDS
Cancer
Raman spectroscopy
Biopsy
Liquids
Biological research
Molecular spectroscopy
Control systems
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