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13 March 2024 Endoscopic polarization sensitive optical coherence tomography for airway smooth muscle quantification in healthy and diseased airways
Tatiana Soldati, Sofi M. Vassileva, Margherita Vaselli, Kirsten A. Kalverda, Pieta P. C. Wijsman, Jouke T. Annema, Peter I. Bonta, Johannes F. de Boer
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Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC1282005 (2024) https://doi.org/10.1117/12.3002931
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
No diagnostic method is currently available to visualize and measure the airway smooth muscle (ASM) within a living patient. Endoscopic Polarization Sensitive Optical Coherence Tomography (PS-OCT) might enable quantification of ASM mass in vivo, by assessing tissue birefringence. We performed in vivo PS-OCT on patients (n=17) with airway diseases (asthma and interstitial lung disease) and one healthy volunteer. An in-house built distal scanning catheter (1.35 mm) was used to circumferentially scan the airways at 52 fps B-scan rate. We demonstrated PS-OCT to be a minimally invasive technique to assess ASM thickness in diseased airways relative to healthy subjects.
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Tatiana Soldati, Sofi M. Vassileva, Margherita Vaselli, Kirsten A. Kalverda, Pieta P. C. Wijsman, Jouke T. Annema, Peter I. Bonta, and Johannes F. de Boer "Endoscopic polarization sensitive optical coherence tomography for airway smooth muscle quantification in healthy and diseased airways", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC1282005 (13 March 2024); https://doi.org/10.1117/12.3002931
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KEYWORDS
Optical coherence tomography
Endoscopy
Muscles
Polarization
Pulmonary disorders
In vivo imaging
Image segmentation
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