Inter-volumetric OCT angiography

Guangru B. Liang; Tristan T. Hormel; Siyu Chen; Yali Jia

doi:10.1117/12.3005592

13 March 2024 Inter-volumetric OCT angiography

Guangru B. Liang, Tristan T. Hormel, Siyu Chen, Yali Jia

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128300O (2024) https://doi.org/10.1117/12.3005592
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

This study presents an exploratory approach to performing optical coherence tomographic angiography (OCTA) using motion contrast between repeated volumetric scans captured at 200 ms intervals, as opposed to conventional OCTA which measure motion contrast between repeat B-scans captured at shorter intervals. The proposed inter-volumetric OCTA (IV-OCTA) is made possible through an advanced image registration algorithm based on Mattes mutual information metric, and it is implemented on an ultra-high-resolution spectral domain 840 nm OCT system with a 250 KHz A-scan rate. IV-OCTA demonstrates a high detection sensitivity for microvessels with slow blood flow and reduces bulk motion artifacts using the embedded volume registration algorithm. Meanwhile, averaging repeated volumes can substantially reduce the speckle noise for clearer structural imaging compared to the averaged repeated B-scans.

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Citation Download Citation

Guangru B. Liang, Tristan T. Hormel, Siyu Chen, and Yali Jia "Inter-volumetric OCT angiography", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128300O (13 March 2024); https://doi.org/10.1117/12.3005592

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KEYWORDS

Optical coherence tomography

Reflectivity

Image registration

Speckle

Angiography

Interference (communication)

Tissues

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