Optical biopsy of brain tumors using fluorescence lifetime imaging (FLIm)

Silvia N. Noble Anbunesan; Alba Alfonso Garcia; Julien Bec; Mohamed Hassan; Lisanne Kraft; Matthew Bobinski; Han Sung Lee; Lee-Way Jin; Orin Bloch; Laura Marcu

doi:10.1117/12.3001898

13 March 2024 Optical biopsy of brain tumors using fluorescence lifetime imaging (FLIm)

Silvia N. Noble Anbunesan, Alba Alfonso Garcia, Julien Bec, Mohamed Hassan, Lisanne Kraft, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu

Author Affiliations +

Proceedings Volume PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII; PC1283101 (2024) https://doi.org/10.1117/12.3001898
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Stereotactic needle biopsy is a time-consuming and invasive procedure that often cannot accurately distinguish recurrent tumors from treatment effect in gliomas. We report an intraoperative multispectral fluorescence lifetime imaging (FLIm) system coupled with a custom-made fiber optic probe integrated with the stealth biopsy needle as an optical biopsy tool. FLIm parameters collected from 3 suspected recurrent glioma patients changed over the biopsy trajectory as the needle passed different brain areas. An SVM classifier validated using a leave-one-patient-out validation scheme could identify the lesions from the normal surrounding tissue with sensitivity=0.99, specificity=0.91, and accuracy=0.95.

Conference Presentation

Citation Download Citation

Silvia N. Noble Anbunesan, Alba Alfonso Garcia, Julien Bec, Mohamed Hassan, Lisanne Kraft, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, and Laura Marcu "Optical biopsy of brain tumors using fluorescence lifetime imaging (FLIm)", Proc. SPIE PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII, PC1283101 (13 March 2024); https://doi.org/10.1117/12.3001898

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