Weighted optimization of irradiance for photodynamic therapy of port wine stains

Linhuan He; Ya Zhou; Xiaoming Hu

doi:10.1117/12.2246156

31 October 2016 Weighted optimization of irradiance for photodynamic therapy of port wine stains

Linhuan He, Ya Zhou, Xiaoming Hu

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100240K (2016) https://doi.org/10.1117/12.2246156
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

Planning of irradiance distribution (PID) is one of the foremost factors for on-demand treatment of port wine stains (PWS) with photodynamic therapy (PDT). A weighted optimization method for PID was proposed according to the grading of PWS with a three dimensional digital illumination instrument. Firstly, the point clouds of lesions were filtered to remove the error or redundant points, the triangulation was carried out and the lesion was divided into small triangular patches. Secondly, the parameters such as area, normal vector and orthocenter for optimization of each triangular patch were calculated, and the weighted coefficients were determined by the erythema indexes and areas of patches. Then, the optimization initial point was calculated based on the normal vectors and orthocenters to optimize the light direction. In the end, the irradiation can be optimized according to cosine values of irradiance angles and weighted coefficients. Comparing the irradiance distribution before and after optimization, the proposed weighted optimization method can make the irradiance distribution match better with the characteristics of lesions, and has the potential to improve the therapeutic efficacy.

Citation Download Citation

Linhuan He, Ya Zhou, and Xiaoming Hu "Weighted optimization of irradiance for photodynamic therapy of port wine stains", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100240K (31 October 2016); https://doi.org/10.1117/12.2246156

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Photodynamic therapy

Optimization (mathematics)

Projection systems

Clouds

Laser therapeutics

Light sources

Optical spheres

Show All Keywords

Keywords/Phrases

Search In:

Publication Years