Optimization on source detector distance for the glucose sensing in a tissue phantom using near-infrared diffuse spectra

Chao Guo; Tongshuai Han; Ziyang Zhang; Di Sun; Jin Liu

doi:10.1117/12.2245862

31 October 2016 Optimization on source detector distance for the glucose sensing in a tissue phantom using near-infrared diffuse spectra

Chao Guo, Tongshuai Han, Ziyang Zhang, Di Sun, Jin Liu

Author Affiliations +

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100242N (2016) https://doi.org/10.1117/12.2245862
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

In the non-invasive blood glucose concentration (BGC) sensing, the measurement based on near infrared spectroscopy has been a promising technology since it had acquired dozens of satisfactory results in short-term glucose monitoring tests. However, it’s still necessary to improve the measurement precision because it has challenges of the reduced precision in a long-term test when a lot of variables in the test would exist. Considering the requirement of multivariable analysis, the signals of diffuse reflectance spectra should include enough absorption information from glucose. However, the sensitivity of diffuse light intensity to the absorption variation at different source detector separations (SDSs) could be different. We present an analysis method using Monte-Carlo (MC) simulation and the diffuse equation for reasonably selecting proper SDS to get a satisfactory glucose measurement precision when there are multivariable disturbances. In the case of measuring glucose in a tissue phantom using the waveband of 1000-1340 nm, we show the SDS optimization result by using this analysis method. The experiment was designed to measure the diffuse reflectance spectra at 0.1-3.0 mm with the step of 0.1 mm, and the phantom solutions with different glucose concentrations and hemoglobin concentrations are tested. The glucose prediction precision was evaluated using the root mean squared error of prediction (RMSEP) for the all SDSs of 0.1-3.0 mm, and the SDSs with the lower RMSEP were selected for use. Moreover, the selected SDSs in the experiment shows a similar conclusion from the MC simulation. This work could be referenced to the in vivo BGC measurement.

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Chao Guo, Tongshuai Han, Ziyang Zhang, Di Sun, and Jin Liu "Optimization on source detector distance for the glucose sensing in a tissue phantom using near-infrared diffuse spectra", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242N (31 October 2016); https://doi.org/10.1117/12.2245862

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KEYWORDS

Glucose

Absorption

Monte Carlo methods

Scattering

Blood

Light scattering

Sensors

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