Frequency domain non-contact photoacoustic microscopy

Deepu George; Harriet Lloyd; Ronald H. Silverman; Parag V. Chitnis

doi:10.1117/12.2253665

3 March 2017 Frequency domain non-contact photoacoustic microscopy

Deepu George, Harriet Lloyd, Ronald H. Silverman, Parag V. Chitnis

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 1006443 (2017) https://doi.org/10.1117/12.2253665
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

We present a non-contact “frequency domain photoacoustic microscope” (Fd-PAM) in which photoacoustic signal is generated by an amplitude modulated continuous-wave (CW) laser and detected at the sample surface using two wave mixing (interferometer) in a photorefractive crystal (PRC). The optical detection eliminates the need for a coupling medium, thus making the probe contactless and mitigates loss in signal-to-noise ratio (SNR) resulting from attenuation associated with wave propagation from the sample to the sensor. The single frequency excitation enables the use of extremely narrow band detection techniques like a lock-in amplifier for noise suppression. Our approach also can image multi-layered specimen and directly produce an image that is equivalent to the maximum-intensity projection of the 3D image volume.

Citation Download Citation

Deepu George, Harriet Lloyd, Ronald H. Silverman, and Parag V. Chitnis "Frequency domain non-contact photoacoustic microscopy ", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006443 (3 March 2017); https://doi.org/10.1117/12.2253665

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available