Light activated microbubbles for imaging and microsurgery

Lucia Cavigli; Filippo Micheletti; Paolo Tortoli; Sonia Centi; Sarah Lai; Claudia Borri; Francesca Rossi; Fulvio Ratto; Roberto Pini

doi:10.1117/12.2252783

3 March 2017 Light activated microbubbles for imaging and microsurgery

Lucia Cavigli, Filippo Micheletti, Paolo Tortoli, Sonia Centi, Sarah Lai, Claudia Borri, Francesca Rossi, Fulvio Ratto, Roberto Pini

Author Affiliations +

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 1006457 (2017) https://doi.org/10.1117/12.2252783
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Imaging and microsurgery procedures based on the photoacoustic effect have recently attracted much attention for cancer treatment. Light absorption in the nanosecond regime triggers thermoelastic processes that induce ultrasound emission and even cavitation. The ultrasound waves may be detected to reconstruct images, while cavitation may be exploited to kill malignant cells. The potential of gold nanorods as contrast agents for photoacoustic imaging has been extensively investigated, but still little is known about their use to trigger cavitation. Here, we investigated the influence of environment thermal properties on the ability of gold nanorods to trigger cavitation by probing the photoacoustic emission as a function of the excitation fluence. We are confident that these results will provide useful directions to the development of new strategies for therapies based on the photoacoustic effect.

Citation Download Citation

Lucia Cavigli, Filippo Micheletti, Paolo Tortoli, Sonia Centi, Sarah Lai, Claudia Borri, Francesca Rossi, Fulvio Ratto, and Roberto Pini "Light activated microbubbles for imaging and microsurgery", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006457 (3 March 2017); https://doi.org/10.1117/12.2252783

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