Brain connectomics imaging in schizophrenia study

Wen-Yih Isaac Tseng; Yu-Jen Chen; Yung-Chin Hsu

doi:10.1117/12.2270425

18 April 2017 Brain connectomics imaging in schizophrenia study

Wen-Yih Isaac Tseng, Yu-Jen Chen, Yung-Chin Hsu

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 1025106 (2017) https://doi.org/10.1117/12.2270425
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

Schizophrenia is a debilitating mental disorder of which the biological underpinning is still unclear. Increasing evidence in neuroscience has indicated that schizophrenia arises from abnormal connections within or between networks, hence called dysconnectvity syndrome. Recently, we established an automatic method to analyze integrity of the white matter tracts over the whole brain based on diffusion MRI data, named tract-based automatic analysis (TBAA), and used this method to study white matter connection in patients with schizophrenia. We found that alteration of tract integrity is hereditary and inherent; it is found in siblings and in patients in the early phase of disease. Moreover, patients with good treatment outcome and those with poor outcome show distinctly different patterns of alterations, suggesting that these two groups of patients might be distinguishable based on the difference in tract alteration. In summary, the altered tracts revealed by TBAA might become potential biomarkers or trait markers for schizophrenia.

Citation Download Citation

Wen-Yih Isaac Tseng, Yu-Jen Chen, and Yung-Chin Hsu "Brain connectomics imaging in schizophrenia study", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 1025106 (18 April 2017); https://doi.org/10.1117/12.2270425

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