In-vivo monitoring of oxygen saturation in murine carcinoma during PDT by diode laser light diffuse reflectance

Vladimir V. Kholin; Oksana M. Chepurna; Irina O. Shton; Valerii S. Voytsehovich; Sergii V. Pavlov; Natalia  I. Zabolotna; Ryszard Romaniuk; Waldemar Wójcik; Yedilkhan Amirgaliyev; Vladimir Kovalev

doi:10.1117/12.2280980

7 August 2017 In-vivo monitoring of oxygen saturation in murine carcinoma during PDT by diode laser light diffuse reflectance

Vladimir V. Kholin, Oksana M. Chepurna, Irina O. Shton, Valerii S. Voytsehovich, Sergii V. Pavlov, Natalia I. Zabolotna, Ryszard Romaniuk, Waldemar Wójcik, Yedilkhan Amirgaliyev, Vladimir Kovalev

Author Affiliations +

Proceedings Volume 10445, Photonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments 2017; 104453N (2017) https://doi.org/10.1117/12.2280980
Event: Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2017, 2017, Wilga, Poland

Abstract

In the paper we explored the possibility of monitoring oxygenation of the tumor tissue through the registration of light diffuse reflectance. This method can also be helpful for assessment the effectiveness of PDT, defining the level of vascular damage and the degree of the tumor oxygenation. We also propose the modification of PDT procedure by using a modulated laser that enables to better maintain the necessary parameters for the PS activation and oxygen generation in irradiated tissues simultaneously allowing to reduce the light dose required for tumor treatment.

Citation Download Citation

Vladimir V. Kholin, Oksana M. Chepurna, Irina O. Shton, Valerii S. Voytsehovich, Sergii V. Pavlov, Natalia I. Zabolotna, Ryszard Romaniuk, Waldemar Wójcik, Yedilkhan Amirgaliyev, and Vladimir Kovalev "In-vivo monitoring of oxygen saturation in murine carcinoma during PDT by diode laser light diffuse reflectance", Proc. SPIE 10445, Photonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments 2017, 104453N (7 August 2017); https://doi.org/10.1117/12.2280980

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Tumors

Photodynamic therapy

Oxygen

Spectroscopy

Modulation

Optical fibers

Picosecond phenomena

Show All Keywords

Keywords/Phrases

Search In:

Publication Years