Ondřej Podrazkyhttps://orcid.org/0000-0003-4255-9366,1 Pavel Peterka,1 Soňa Vytykáčová,1 Jana Proboštová,1 Martin Kuneš,2,3 Oleksiy Lyutakov,4 Edoardo Ceci-Ginistrelli,5 Diego Pugliese,5 Nadia G. Boetti,6 Davide Janner,5 Daniel Milanese5,7
1Institute of Photonics and Electronics of the ASCR, v.v.i. (Czech Republic) 2Univ. Hospital Hradec Králové (Czech Republic) 3Univ. of Pardubice (Czech Republic) 4Institute of Chemical Technology (Czech Republic) 5Politecnico di Torino (Italy) 6Istituto Superiore Mario Boella (Italy) 7Istituto di Fotonica e Nanotecnologie, CNR (Italy)
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We report on the employment of a biodegradable phosphate-based optical fiber as a pH sensing probe in physiological environment. The phosphate-based optical fiber preform was fabricated by the rod-in-tube technique. The fiber biodegradability was first tested in-vitro and then its biodegradability and toxicity were tested in-vivo. Optical probes for pH sensing were prepared by the immobilization of a fluorescent dye on the fiber tip by a sol-gel method. The fluorescence response of the pH-sensor was measured as a ratio of the emission intensities at the excitation wavelengths of 405 and 450 nm.
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Ondřej Podrazky, Pavel Peterka, Soňa Vytykáčová, Jana Proboštová, Martin Kuneš, Oleksiy Lyutakov, Edoardo Ceci-Ginistrelli, Diego Pugliese, Nadia G. Boetti, Davide Janner, Daniel Milanese, "Biomedical and sensing applications of a multi-mode biodegradable phosphate-based optical fiber," Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880H (13 February 2018); https://doi.org/10.1117/12.2285148