Tissue Distribution Of Chloroaluminium Sulfonated Phthalocyanine In Dogs

S. W. Crane; M. M. Zuk; H. C. Newman; I. Rosenthal; E. Ben-Hur

doi:10.1117/12.978019

13 June 1989 Tissue Distribution Of Chloroaluminium Sulfonated Phthalocyanine In Dogs

S. W. Crane, M. M. Zuk, H. C. Newman, I. Rosenthal, E. Ben-Hur

Proceedings Volume 1065, Photodynamic Therapy: Mechanisms; (1989) https://doi.org/10.1117/12.978019
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

Chloroaluminum sulfonated phthalocyanine (A1PCS) was administered intravenously to clinically normal dogs, and A1PCS levels were determined in tissues using a sensitive assay. A1PCS accumulated to high levels in liver, spleen, bone marrow, kidney, and lung. These tissue levels confirm previous determinations in mice and rats. Only a small amount of dye was retained in skin and very small amounts in muscle and brain. A1PCS was cleared from the blood within 24 h, and excreted primarily by urine. Serum clearance was faster in males than in females. There were also significant tissue distribution differences between the genders, particularly during the first 12 h. The low levels of A1PCS in skin suggest that cutaneous photosensitivity and toxic skin reactions using this photosensitizer in photodynamic therapy of cancer may be eliminated. The difference in tissue distribution between genders is not only intriguing, but indicates that the optimal time window for treatment of various tissue sites may vary by gender.

Citation Download Citation

S. W. Crane, M. M. Zuk, H. C. Newman, I. Rosenthal, and E. Ben-Hur "Tissue Distribution Of Chloroaluminium Sulfonated Phthalocyanine In Dogs", Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); https://doi.org/10.1117/12.978019

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