Fluorescence lifetime imaging microscopy along with non-Euclidean phasor analysis for visualization of drug distribution of a topical drug in human facial skin (Conference Presentation)

Sinyoung Jeong; Alexander Fast; Sam Osseiran; Maiko Hermsmeier; Tanvee Sawant; Kin F. Chan; Conor L. Evans

doi:10.1117/12.2510218

4 March 2019 Fluorescence lifetime imaging microscopy along with non-Euclidean phasor analysis for visualization of drug distribution of a topical drug in human facial skin (Conference Presentation)

Sinyoung Jeong, Alexander Fast, Sam Osseiran, Maiko Hermsmeier, Tanvee Sawant, Kin F. Chan, Conor L. Evans

Author Affiliations +

Proceedings Volume 10859, Visualizing and Quantifying Drug Distribution in Tissue III; 1085908 (2019) https://doi.org/10.1117/12.2510218
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We recently proposed a method for selective visualization of topical drug distribution within human facial skin using two-photon fluorescence lifetime imaging along with non-Euclidean phasor analysis as a pharmacokinetics and pharmacodynamics imaging toolkit. In order to improve the efficacy of topical drug delivery toward the treatment of inflammatory acne, we have now developed a combination topical gel containing both minocycline and a retinoid. Since both drugs have unique fluorescence lifetimes compared to skin, we were able to selectively visualize the distribution of minocycline and the retinoid within ex vivo human facial skin while isolating the contributions of the three components.

Conference Presentation

Citation Download Citation

Sinyoung Jeong, Alexander Fast, Sam Osseiran, Maiko Hermsmeier, Tanvee Sawant, Kin F. Chan, and Conor L. Evans "Fluorescence lifetime imaging microscopy along with non-Euclidean phasor analysis for visualization of drug distribution of a topical drug in human facial skin (Conference Presentation)", Proc. SPIE 10859, Visualizing and Quantifying Drug Distribution in Tissue III, 1085908 (4 March 2019); https://doi.org/10.1117/12.2510218

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available