Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo

Arvid Lindberg; Jérémy Vizet; Jean Rehbinder; Camille Gennet; Jean-Charles Vanel; Angelo Pierangelo

doi:10.1117/12.2510232

4 March 2019 Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo

Arvid Lindberg, Jérémy Vizet, Jean Rehbinder, Camille Gennet, Jean-Charles Vanel, Angelo Pierangelo

Proceedings Volume 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 108730J (2019) https://doi.org/10.1117/12.2510232
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Mueller Polarimetric Imaging (MPI) showed promising results in biomedical applications, especially for early detection of precancerous lesions on biological tissues. This technique is label-free, non-invasive and can be implemented with a large field of view (up to several cm²) to image wide areas of biological tissues while providing information on its microstructure. The development of innovative (MPI) systems, able to analyze biological tissues in vivo on human patients, remains an instrumental challenge. Our goal is to build miniaturized and compact full-field MPI systems based on Ferroelectric Liquid Crystals (FLCs) capable of performing a multispectral accurate analysis of biological tissues in vivo. In this work, an innovative approach is showed to realize optimized and fast FLCs-based MPI systems able to perform full-field imaging acquisitions in the spectral range between 450 and 700nm with error less than 1% on all the elements of measured Mueller matrices. This system can be accurately calibrated by using the Eigenvalue Calibration Method (ECM) also in presence of high residual instrumental depolarization. This approach enables us to realize compact and reliable MPI systems which can be easily integrated into existing instruments currently used in medical practice.

Conference Presentation

Citation Download Citation

Arvid Lindberg, Jérémy Vizet, Jean Rehbinder, Camille Gennet, Jean-Charles Vanel, and Angelo Pierangelo "Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo ", Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 108730J (4 March 2019); https://doi.org/10.1117/12.2510232

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