A multi spectral hand-held spatial frequency domain imaging system for imaging human colorectal cancer

Yifeng Zeng; Shuying Li; Mohsen Erfanzadeh; Sreyankar Nandy; William Chapman Jr.; Zahra Alipour; Heba Abdelal; Deyali Chatterjee; Matthew Mutch; Quing Zhu

doi:10.1117/12.2510320

1 March 2019 A multi spectral hand-held spatial frequency domain imaging system for imaging human colorectal cancer

Yifeng Zeng, Shuying Li, Mohsen Erfanzadeh, Sreyankar Nandy, William Chapman Jr., Zahra Alipour, Heba Abdelal, Deyali Chatterjee, Matthew Mutch, Quing Zhu

Author Affiliations +

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108740T (2019) https://doi.org/10.1117/12.2510320
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

A multi-spectral, portable, hand-held LED based spatial frequency domain imaging system was used for ex vivo imaging pretreatment and post treatment human colon and rectal tissues. Freshly excised human colon and rectal tissue samples were imaged with the hand-held SFDI probe with 9 wavelengths extending from visible to NIR (660-950 nm). Important tumor biomarkers such as hemoglobin, scatter amplitude, scatter spectral slope, water and lipid content were quantitatively extracted from the SFDI absorption and scattering images. Significant differences were observed between the absorption as well as scattering distribution of normal, tumor and polyp tissue as well as between pretreated and post-treated tumors.

Citation Download Citation

Yifeng Zeng, Shuying Li, Mohsen Erfanzadeh, Sreyankar Nandy, William Chapman Jr., Zahra Alipour, Heba Abdelal, Deyali Chatterjee, Matthew Mutch, and Quing Zhu "A multi spectral hand-held spatial frequency domain imaging system for imaging human colorectal cancer", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108740T (1 March 2019); https://doi.org/10.1117/12.2510320

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
3 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Imaging systems

Tissues

Colon

Colorectal cancer

Tumors

Absorption

Scattering

Show All Keywords

Keywords/Phrases

Search In:

Publication Years