Tumor growth monitoring using polarized light

Briséis Varin; Jean Rehbinder; Jean Dellinger; Christian Heinrich; Jordane Schmidt; Caroline Spenlé; Dominique Bagnard; Jihad Zallat

doi:10.1117/12.2527020

22 July 2019 Tumor growth monitoring using polarized light

Briséis Varin, Jean Rehbinder, Jean Dellinger, Christian Heinrich, Jordane Schmidt, Caroline Spenlé, Dominique Bagnard, Jihad Zallat

Author Affiliations +

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110750T (2019) https://doi.org/10.1117/12.2527020
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

The process of tumor growth is a phenomenon which, if understood better, could greatly improve the diagnostic and treatment of patients. In this context, the use of polarimetric imaging can offer more information than classical imaging methods. Here we use a new kind of calibration-free spectro-polarimeter which can be helpful for optical biopsy. Fifty different mice have been studied in full Mueller polarimetry with this device. Some were injected with very pigmented melanoma cells, others with non-pigmented breast cancer cells. Variations in depolarization were measured throughout this study: melanomas were accompanied with intense drops in depolarization, while mice injected with breast cancer cells showed a more diffuse decrease in depolarization. The study confirmed the potential of polarimetric imaging as an optical biopsy tool.

Citation Download Citation

Briséis Varin, Jean Rehbinder, Jean Dellinger, Christian Heinrich, Jordane Schmidt, Caroline Spenlé, Dominique Bagnard, and Jihad Zallat "Tumor growth monitoring using polarized light", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110750T (22 July 2019); https://doi.org/10.1117/12.2527020

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