Label-free imaging of collagen as a potential diagnostic marker for detection of gliomas

Na Fang; Zanyi Wu; Xingfu Wang; Dezhi Kang; Yuanxiang Lin; Jianxin Chen

doi:10.1117/12.2551593

20 December 2019 Label-free imaging of collagen as a potential diagnostic marker for detection of gliomas

Na Fang, Zanyi Wu, Xingfu Wang, Dezhi Kang, Yuanxiang Lin, Jianxin Chen

Proceedings Volume 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019); 112095L (2019) https://doi.org/10.1117/12.2551593
Event: Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 2019, Xi'an, China

Abstract

The collagen in glioma is changed due to remodeling of the extracellular matrix during the malignant process and plays an important role in the progression of human gliomas. In this paper, multiphoton microscopy (MPM) based on twophoton excited fluorescence (TPEF) and second harmonic generation (SHG) was introduced to image the changes of collagen in normal human brain and gliomas. What’s more, together with the image analysis, the collagen content was quantitatively measured. It was found that in gliomas the collagen content significantly increased compared to normal brain tissue. These results suggest that MPM has the capability to provide collagen signature as a potential diagnostic marker for detection of gliomas.

Citation Download Citation

Na Fang, Zanyi Wu, Xingfu Wang, Dezhi Kang, Yuanxiang Lin, and Jianxin Chen "Label-free imaging of collagen as a potential diagnostic marker for detection of gliomas", Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 112095L (20 December 2019); https://doi.org/10.1117/12.2551593

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