Estimating paired-agent uptake in altered tumor vasculature using MRI-coupled fluorescence tomography

Boyu Meng; Rendall R. Strawbridge; Kenneth Tichauer; Kimberley S. Samkoe; Scott C. Davis

doi:10.1117/12.2546702

2 March 2020 Estimating paired-agent uptake in altered tumor vasculature using MRI-coupled fluorescence tomography

Boyu Meng, Rendall R. Strawbridge, Kenneth Tichauer, Kimberley S. Samkoe, Scott C. Davis

Proceedings Volume 11216, Multiscale Imaging and Spectroscopy; 112160U (2020) https://doi.org/10.1117/12.2546702
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Angiogenesis inhibiting cancer therapy has become a standard treatment for many cancer types. The ability to examine the effects of these drugs in tumors noninvasively could help assess efficacy early in the treatment course or identify optimal times to introduce other combinatorial treatments. Herein, we examine whether a paired agent MRI-coupled fluorescence tomography approach can be used to monitor the effects of anti-angiogenesis therapy. Using small animal models bearing orthotopic glioma xenografts, we demonstrate noninvasive quantification of paired-agent uptake in response to anti-angiogenesis therapy in vivo. The result provides insights on receptor targeted drug delivery in altered vasculature, a potential important development for treatment monitoring and combinatorial strategies.

Conference Presentation

Citation Download Citation

Boyu Meng, Rendall R. Strawbridge, Kenneth Tichauer, Kimberley S. Samkoe, and Scott C. Davis "Estimating paired-agent uptake in altered tumor vasculature using MRI-coupled fluorescence tomography", Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 112160U (2 March 2020); https://doi.org/10.1117/12.2546702

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