Comparing the efficacy of infrared diode and Ho:YAG lasers for infrared neural stimulation (Conference Presentation)

Graham A. Throckmorton; Wilson R. Adams; Zane C. Ricks; Jonathan M. Cayce; E. Duco Jansen; Anita Mahadevan-Jansen

doi:10.1117/12.2546270

9 March 2020 Comparing the efficacy of infrared diode and Ho:YAG lasers for infrared neural stimulation (Conference Presentation)

Graham A. Throckmorton, Wilson R. Adams, Zane C. Ricks, Jonathan M. Cayce, E. Duco Jansen, Anita Mahadevan-Jansen

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Proceedings Volume 11227, Optogenetics and Optical Manipulation 2020; 112270R (2020) https://doi.org/10.1117/12.2546270
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Infrared neural stimulation (INS) has the potential to serve as a spatially precise tool for neuroscientists and clinicians. Because of difficulties comparing various INS techniques in the current literature, we present a study comparing the stimulation threshold and transition rate to 100% activation probability for diode and Ho:YAG lasers. The stimulation threshold was lower for the Ho:YAG than the diode lasers across all examined spot sizes. The Ho:YAG also exhibited a nearly binary transition to 100% activation that can be mimicked with diode lasers by decreasing the pulse width. These results will help maximize the performance of laser diodes for INS.

Conference Presentation

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Graham A. Throckmorton, Wilson R. Adams, Zane C. Ricks, Jonathan M. Cayce, E. Duco Jansen, and Anita Mahadevan-Jansen "Comparing the efficacy of infrared diode and Ho:YAG lasers for infrared neural stimulation (Conference Presentation)", Proc. SPIE 11227, Optogenetics and Optical Manipulation 2020, 112270R (9 March 2020); https://doi.org/10.1117/12.2546270

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KEYWORDS

Semiconductor lasers

Infrared radiation

Diodes

Infrared lasers

Laser damage threshold

Animal model studies

In vivo imaging

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