A lock-in photon-counting based single pixel imaging toward real-time multi-wavelength SFD-DOT

Mai Dan; Tongxin Li; Xi Hou; Feng Gao

doi:10.1117/12.2541785

21 February 2020 A lock-in photon-counting based single pixel imaging toward real-time multi-wavelength SFD-DOT

Mai Dan, Tongxin Li, Xi Hou, Feng Gao

Proceedings Volume 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 112341L (2020) https://doi.org/10.1117/12.2541785
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We have developed a real-time multi-wavelength spatial frequency domain (SFD) diffuse optical tomography (DOT) to characterize the optical properties of biological tissues, using single-pixel imaging based on lock-in photon-counting. In our approach, three laser diodes at wavelengths of 450 nm, 520 nm and 635 nm, are intensity-modulated by square waves of three frequencies (temporal-encoding), respectively, and focused into the first digital micromirror device (DMD) to generate a sinusoidal illumination pattern at selected spatial frequencies. The reflected light from the surface of turbid medium are spatially integrated by the second DMD, successively using sampling patterns based on the two- dimensional discrete cosine transform (DCT) bases around the spatial modulation frequencies (spatial-compressing). The temporally encoded and spatially compressed multi-wavelength signals that are detected from photomultiplier tube are firstly demodulated by a highly-sensitive lock-in photon-counting module for temporal-decoding, and then uncompressed into the spatial frequency domain images by the inverse DCT, from which tomographic images of the absorption coefficient are finally reconstructed using the first-order Rytov approximation of the diffusion equation. The phantom experiments show that the proposed method can achieve a reconstruction error within 10%, and a temporal resolution of less than 10 s.

Citation Download Citation

Mai Dan, Tongxin Li, Xi Hou, and Feng Gao "A lock-in photon-counting based single pixel imaging toward real-time multi-wavelength SFD-DOT", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112341L (21 February 2020); https://doi.org/10.1117/12.2541785

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Absorption

Modulation

Spatial frequencies

Signal detection

Tissues

Light sources

Tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years