The toxicity and clearance of copper indium sulfide quantum dots in vivo (Conference Presentation)

Joshua Kays; Alexander M. Saeboe; Reyhaneh Toufanian; Allison M. Dennis

doi:10.1117/12.2546747

10 March 2020 The toxicity and clearance of copper indium sulfide quantum dots in vivo (Conference Presentation)

Joshua Kays, Alexander M. Saeboe, Reyhaneh Toufanian, Allison M. Dennis

Proceedings Volume 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII; 112560B (2020) https://doi.org/10.1117/12.2546747
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

For the first time, we assess the biodistribution and toxicity of unshelled CIS and partially zinc-alloyed CISZ QDs in a murine model at 1-day, 7-day, and 1-month timepoints. We show that bare CIS QDs breakdown quickly, with >75% of the initial dose being cleared by 1-month. Surprisingly, we also demonstrate a significant toxic response to these QDs as measured by organ weight, blood chemistry, and histology. Specifically, low doses of CIS particles (15mg/kg) induce severe hepatotoxicity and splenotoxicity. Similarly, CISZ demonstrated significant, but lower, toxicity compared to bare CIS. Overall, our data suggests that reconsideration of CIS as a translatable QD system is required: degradation-based toxicity is an important aspect of biocompatibility that needs to be assessed in “non-toxic” QDs, if QDs are to ever be clinically successful. Finally, we suggest a non-toxic biodegradable alternative.

Conference Presentation

Citation Download Citation

Joshua Kays, Alexander M. Saeboe, Reyhaneh Toufanian, and Allison M. Dennis "The toxicity and clearance of copper indium sulfide quantum dots in vivo (Conference Presentation)", Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 112560B (10 March 2020); https://doi.org/10.1117/12.2546747

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KEYWORDS

Copper indium disulfide

Toxicity

Copper

In vivo imaging

Indium

Quantum dots

Near infrared

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