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10 March 2020 Red blood cell membranes-camouflaged gold nanostars for enhanced photoacoustic diagnosis and photothermal treatment of liver cancer (Conference Presentation)
Xiazi Huang, Puxiang Lai
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Proceedings Volume 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII; 112560D (2020) https://doi.org/10.1117/12.2545469
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
A biomimetic photoacoustic nano-probe is synthesized for enhanced the diagnostic accuracy of hepatocellular carcinoma. It is prepared by using erythrocyte membrane to coat the gold nano-star which shows significant photothermal effect. This probe can escape the clearance by mononuclear phagocytic system because of the inherent proteins on the surface of the erythrocyte membrane. Such an ability to evade immune clearance allows a longer circulation time in vivo, promotes probe enrichment at tumor site, and improves signal-to-noise ratio. Sequentially, it is used as an agent of non-invasive photothermal treatment for tumor and experimentally perform a longer life span of mice.
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Xiazi Huang and Puxiang Lai "Red blood cell membranes-camouflaged gold nanostars for enhanced photoacoustic diagnosis and photothermal treatment of liver cancer (Conference Presentation)", Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 112560D (10 March 2020); https://doi.org/10.1117/12.2545469
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KEYWORDS
Blood
Gold
Liver cancer
Photoacoustic spectroscopy
Nanoparticles
Diagnostics
In vivo imaging
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