Hyper-Raman optical activity of biologically relevant chiral molecules

Christopher B. Marble; Xingqi Xu; Mark Keppler; Eddie Gil; Georgi I. Petrov; Dawei Wang; Vladislav V. Yakovlev

doi:10.1117/12.2545530

3 March 2020 Hyper-Raman optical activity of biologically relevant chiral molecules

Christopher B. Marble, Xingqi Xu, Mark Keppler, Eddie Gil, Georgi I. Petrov, Dawei Wang, Vladislav V. Yakovlev

Proceedings Volume 11288, Quantum Sensing and Nano Electronics and Photonics XVII; 1128829 (2020) https://doi.org/10.1117/12.2545530
Event: SPIE OPTO, 2020, San Francisco, California, United States

Abstract

The optical activity of Raman scattering provides insight into the absolute configuration and conformation of chiral molecules. Applications of Raman optical activity (ROA) are limited by long integration times due to a relatively low sensitivity of the scattered light to chirality (typically 10^-3 to 10^-5). We apply ROA techniques to hyper-Raman scattering using incident circularly polarized light and a right-angle scattering geometry. We explore the sensitivity of hyper- Raman scattering to chirality as compared to spontaneous Raman optical activity. Using the excitation wavelength at around 532 nm, the photobleaching is minimized, while the hyper-Raman scattering benefits from the electronic resonant enhancement. For S/R-2-butanol and L/D-tartaric acid, we were unable to detect the hyper-Raman optical activity at the sensitivity level of 1%. We also explored parasitic thermal effects which can be mitigating by varying the repetition rate of the laser source used for excitation of hyper-Raman scattering.

Citation Download Citation

Christopher B. Marble, Xingqi Xu, Mark Keppler, Eddie Gil, Georgi I. Petrov, Dawei Wang, and Vladislav V. Yakovlev "Hyper-Raman optical activity of biologically relevant chiral molecules", Proc. SPIE 11288, Quantum Sensing and Nano Electronics and Photonics XVII, 1128829 (3 March 2020); https://doi.org/10.1117/12.2545530

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