Quantitative Infrared Spectroscopy Of Glucose In Blood Using Partial Least-Squares Analyses

Kenneth J. Ward; David M. Haaland; M. Ries Robinson; R. Philip Eaton

doi:10.1117/12.969626

1 December 1989 Quantitative Infrared Spectroscopy Of Glucose In Blood Using Partial Least-Squares Analyses

Kenneth J. Ward, David M. Haaland, M. Ries Robinson, R. Philip Eaton

Proceedings Volume 1145, 7th Intl Conf on Fourier Transform Spectroscopy; (1989) https://doi.org/10.1117/12.969626
Event: Seventh International Conference on Fourier and Computerized Infrared Spectroscopy, 1989, Fairfax, VA, United States

Abstract

The concentration of glucose in drawn samples of human blood has been determined using attenuated total reflectance (ATR) Fourier transform infrared (FT-IR) spectroscopy and partial least-squares (PLS) multivariate calibration. A twelve sample calibration set over the physiological glucose range of 50-400 mg/deciliter (dl) resulted in an average error of 5.24 mg/dl. These results were obtained using cross validated PLS calibration for all data in the frequency range of 950-1200 cm-1. These results are a dramatic improvement relative to those obtained by previous studies of this system using univariate peak height analyses.

Citation Download Citation

Kenneth J. Ward, David M. Haaland, M. Ries Robinson, and R. Philip Eaton "Quantitative Infrared Spectroscopy Of Glucose In Blood Using Partial Least-Squares Analyses", Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); https://doi.org/10.1117/12.969626

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