Assessing pharmacokinetics of indocyanine green in liver injury mice using dynamic diffuse fluorescence tomography system

Ke Shi; Limin Zhang; Zhichao Zhao; Bin Cao; Nan Chen; Jiao Li; Zhongxing Zhou; Feng Gao

doi:10.1117/12.2574153

10 October 2020 Assessing pharmacokinetics of indocyanine green in liver injury mice using dynamic diffuse fluorescence tomography system

Ke Shi, Limin Zhang, Zhichao Zhao, Bin Cao, Nan Chen, Jiao Li, Zhongxing Zhou, Feng Gao

Author Affiliations +

Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 115532B (2020) https://doi.org/10.1117/12.2574153
Event: SPIE/COS Photonics Asia, 2020, Online Only

Conference Poster

Abstract

Fluorescence pharmacokinetics can analyze the absorption, distribution, metabolism and other pharmacokinetic processes of fluorescence agents in biological tissues over time, which can provide more specific and quantitative physiological and pathological information for the evaluation of organ function. This paper is devoted to studying pharmacokinetics of indocyanine green (ICG) in healthy mice and mice with acute alcoholic liver injury based on a home-made dynamic diffuse fluorescence tomography system that possesses high sensitivity and large dynamic measurement range on account of digital lock-in-photon-counting technique. In this study, four-week-old Kunming mice were randomly divided into experimental and control groups. The time-varying distribution of ICG in mice was obtained by diffuse fluorescence tomography reconstruction, and the pharmacokinetic parameters were further extracted from the ICG concentration-time curve. The results showed that the dynamic diffuse fluorescence tomography system successfully captured the ICG metabolism process in mouse liver, and the ICG excretion rate demonstrated an obvious difference between healthy mice and the mice with acute alcoholic liver injury.

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Ke Shi, Limin Zhang, Zhichao Zhao, Bin Cao, Nan Chen, Jiao Li, Zhongxing Zhou, and Feng Gao "Assessing pharmacokinetics of indocyanine green in liver injury mice using dynamic diffuse fluorescence tomography system", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 115532B (10 October 2020); https://doi.org/10.1117/12.2574153

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