1.7-micron optical coherence tomography angiography for characterization of skin cancer

Yan Li; Yirui Zhu; Fengyi Zhang; Jianing Tang; Joseph Mehrabi; Kristen Kelly; Zhongping Chen

doi:10.1117/12.2576449

5 March 2021 1.7-micron optical coherence tomography angiography for characterization of skin cancer

Yan Li, Yirui Zhu, Fengyi Zhang, Jianing Tang, Joseph Mehrabi, Kristen Kelly, Zhongping Chen

Proceedings Volume 11618, Photonics in Dermatology and Plastic Surgery 2021; 1161809 (2021) https://doi.org/10.1117/12.2576449
Event: SPIE BiOS, 2021, Online Only

Abstract

Optical coherence tomography (OCT) is a non-invasive diagnostic method that offers real-time visualization of the layered architecture of the skin in vivo. The 1.7-micron OCT system has been applied in cardiology, gynecology and dermatology, demonstrating an improved penetration depth in contrast to conventional 1.3-micron OCT. To further extend the capability, we developed a 1.7-micron OCT/OCT angiography (OCTA) system that allows for a visualization of both morphology and microvasculature in the deeper layers of the skin. Using this imaging system, we imaged human skin with different benign lesions and described the corresponding features of both structure and vasculature. The significantly improved imaging depth and additional functional information suggest that the 1.7-micron OCTA system has great potential to advance both dermatological clinical and research settings for characterization of benign and cancerous skin lesions.

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Citation Download Citation

Yan Li, Yirui Zhu, Fengyi Zhang, Jianing Tang, Joseph Mehrabi, Kristen Kelly, and Zhongping Chen "1.7-micron optical coherence tomography angiography for characterization of skin cancer", Proc. SPIE 11618, Photonics in Dermatology and Plastic Surgery 2021, 1161809 (5 March 2021); https://doi.org/10.1117/12.2576449

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KEYWORDS

Optical coherence tomography

Angiography

Skin

Skin cancer

Imaging systems

Visualization

Clinical research

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