Structured illumination microscopy for see-and-treat decision making in localized prostate cancer therapy

Madeline Behr; Shams K. Halat; L. Spencer Krane; J. Quincy Brown

doi:10.1117/12.2577746

5 March 2021 Structured illumination microscopy for see-and-treat decision making in localized prostate cancer therapy

Madeline Behr, Shams K. Halat, L. Spencer Krane, J. Quincy Brown

Proceedings Volume 11619, Advanced Photonics in Urology; 1161905 (2021) https://doi.org/10.1117/12.2577746
Event: SPIE BiOS, 2021, Online Only

Abstract

Accurate detection and diagnosis of prostate cancer remains challenging even with MRI fusion ultrasound biopsy procedures. These challenges contribute to diagnostic errors that can lead to repeat procedures. This study explores the application of ex vivo structured illumination microscopy (SIM) to generate pathology images of fresh biopsies to inform diagnostic decisions. Samples from the lesion of interest and a benign area of each patient were obtained, stained with fluorescent H&E analog dyes, imaged on a custom SIM system and diagnosed by a pathologist. This procedure could be extrapolated to a “see-and-treat” paradigm for localized prostate cancer ablation in the future.

Conference Presentation

Citation Download Citation

Madeline Behr, Shams K. Halat, L. Spencer Krane, and J. Quincy Brown "Structured illumination microscopy for see-and-treat decision making in localized prostate cancer therapy", Proc. SPIE 11619, Advanced Photonics in Urology, 1161905 (5 March 2021); https://doi.org/10.1117/12.2577746

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