CD117-targeted intraoperative imaging of gastrointestinal stromal tumor using zwitterionic near-infrared fluorophores

Shinya Yokomizo; Shinsuke Nomura; Zhidong Wang; Homan Kang; Kai Bao; Chengeng Yang; Kazumasa Inoue; Masahiro Fukushi; Satoshi Kashiwagi; Hak Soo Choi

doi:10.1117/12.2578416

5 March 2021 CD117-targeted intraoperative imaging of gastrointestinal stromal tumor using zwitterionic near-infrared fluorophores

Shinya Yokomizo, Shinsuke Nomura, Zhidong Wang, Homan Kang, Kai Bao, Chengeng Yang, Kazumasa Inoue, Masahiro Fukushi, Satoshi Kashiwagi, Hak Soo Choi

Author Affiliations +

Proceedings Volume 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII; 116250O (2021) https://doi.org/10.1117/12.2578416
Event: SPIE BiOS, 2021, Online Only

Abstract

Accurate mapping of gastrointestinal stromal tumors (GIST) during surgery is difficult, which contributes to the suboptimal diagnosis and recurrence of cancers. To overcome this limitation, we developed a near-infrared (NIR) fluorescent nanoprobe for real-time navigation of GIST using a targeted strategy against the CD117 ligand stem cell factor (SCF). A zwitterionic NIR fluorophore conjugated to SCF showed specific binding to a xenograft mouse model of CD117-positive GIST-T1 with minimal nonspecific tissue signals. This promising intraoperative imaging strategy could be further explored for early diagnosis and follow-up of GIST prognosis before and after surgical resection.

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Shinya Yokomizo, Shinsuke Nomura, Zhidong Wang, Homan Kang, Kai Bao, Chengeng Yang, Kazumasa Inoue, Masahiro Fukushi, Satoshi Kashiwagi, and Hak Soo Choi "CD117-targeted intraoperative imaging of gastrointestinal stromal tumor using zwitterionic near-infrared fluorophores", Proc. SPIE 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII, 116250O (5 March 2021); https://doi.org/10.1117/12.2578416

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