Despite heavy focus on the photochemical and photoelectrical mechanisms of Photobiomodulation (PBMt) and Photodynamic therapies (PDt), minimal attention has been paid to photophysical pathways. In this presentation, we will discuss non-visual phototransduction pathways including mechanotransduction, biophotonic signalling, and light-indued micro-oscillation mechanisms related to PBMt and PDt. We will also discuss the implications of these mechanisms in pathological conditions such as Parkinson’s disease, migraine with aura, and fibromyalgia, and Crigler-Najjar syndrome, and how PBMt may be effective as a potential therapy.
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