Raman spectroscopy based molecular bar coding: realizing the value of high wavenumber region in breast cancer detection

Rishikesh Pandey; Gary Root; Machele Riccio; Michael Sapack; Noel Daigneault; David Fournier; Patrick Curry; Alan Kersey

doi:10.1117/12.2578933

5 March 2021 Raman spectroscopy based molecular bar coding: realizing the value of high wavenumber region in breast cancer detection

Rishikesh Pandey, Gary Root, Machele Riccio, Michael Sapack, Noel Daigneault, David Fournier, Patrick Curry, Alan Kersey

Author Affiliations +

Proceedings Volume 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX; 1163105 (2021) https://doi.org/10.1117/12.2578933
Event: SPIE BiOS, 2021, Online Only

Abstract

Here we present a ratiometric intensity analysis of the Raman spectrum in the HWN region of three breast tissue conditions, namely adipose, fibrous and malignant in a broad sampling of lumpectomy specimens. We demonstrate that these intensity ratios can be used as a “molecular barcode” in breast cancer pathology. Our ratiometric-based approach in HWN is simple, interpretable and exhibits distinct barcodes for different tissue types.

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Citation Download Citation

Rishikesh Pandey, Gary Root, Machele Riccio, Michael Sapack, Noel Daigneault, David Fournier, Patrick Curry, and Alan Kersey "Raman spectroscopy based molecular bar coding: realizing the value of high wavenumber region in breast cancer detection", Proc. SPIE 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, 1163105 (5 March 2021); https://doi.org/10.1117/12.2578933

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