Hematocrit significantly confounds diffuse correlation spectroscopy measurements of blood flow

Eashani Sathialingam; Evelyn K. Williams; Seung Yup Lee; Courtney E. McCracken; Wilbur A. Lam; Erin M. Buckley

doi:10.1117/12.2577049

5 March 2021 Hematocrit significantly confounds diffuse correlation spectroscopy measurements of blood flow

Eashani Sathialingam, Evelyn K. Williams, Seung Yup Lee, Courtney E. McCracken, Wilbur A. Lam, Erin M. Buckley

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390W (2021) https://doi.org/10.1117/12.2577049
Event: SPIE BiOS, 2021, Online Only

Abstract

Diffuse correlation spectroscopy (DCS) is an optical modality used to measure an index of blood flow in biological tissue. This blood flow index depends on both the red blood cell flow rate and density (i.e., hematocrit), although the functional form of hematocrit dependence is not well delineated. Herein, we develop and validate a novel tissue-simulating phantom containing hundreds of microchannels to investigate the influence of hematocrit on blood flow index. For a fixed flow rate, we demonstrate a significant inverse relationship between hematocrit and blood flow index that must be accounted for to accurately estimate blood flow under anemic conditions.

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Eashani Sathialingam, Evelyn K. Williams, Seung Yup Lee, Courtney E. McCracken, Wilbur A. Lam, and Erin M. Buckley "Hematocrit significantly confounds diffuse correlation spectroscopy measurements of blood flow", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390W (5 March 2021); https://doi.org/10.1117/12.2577049

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KEYWORDS

Blood circulation

Spectroscopy

Blood

Dynamic light scattering

Light scattering

Tissue optics

Tissues

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