Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

Weikai Xue; Jonas Ogien; Pavel Bulkin; Anne-Lise Coutrot; Arnaud Dubois

doi:10.1117/12.2608747

7 March 2022 Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

Weikai Xue, Jonas Ogien, Pavel Bulkin, Anne-Lise Coutrot, Arnaud Dubois

Author Affiliations +

Proceedings Volume 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; 119480G (2022) https://doi.org/10.1117/12.2608747
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

Line-field confocal optical coherence tomography (LC-OCT) is a high-resolution imaging technique based on a combination of time-domain optical coherence tomography and confocal optical microscopy, with line illumination using a spatially coherent broadband light source and line detection using a line camera. We present a LC-OCT device based on a Mirau interferometer consisting of an immersion microscope objective incorporating a miniature interferometer. The device can acquire 17 B-scans per second, which is the fastest acquisition rate reported to date in LC-OCT. By stacking multiple adjacent B-scans, a 3D image with a lateral field of view of 940 μm × 600 μm over a depth of 350 μm can be acquired. Compared to the conventional LC-OCT devices based on a Linnik interferometer, this Mirau-based device has advantages in terms of compactness, weight, and B-scan acquisition speed. Imaging of skin tissue with near-isotropic resolution of ~1.5 micron is demonstrated in vivo.

Citation Download Citation

Weikai Xue, Jonas Ogien, Pavel Bulkin, Anne-Lise Coutrot, and Arnaud Dubois "Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging", Proc. SPIE 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, 119480G (7 March 2022); https://doi.org/10.1117/12.2608747

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