Development of a portable, non-contact diffuse reflectance system for tissue spectroscopy

Bradley Clemson; Michael Mrsan; Karthik Vishwanath

doi:10.1117/12.2610438

2 March 2022 Development of a portable, non-contact diffuse reflectance system for tissue spectroscopy

Bradley Clemson, Michael Mrsan, Karthik Vishwanath

Proceedings Volume 11953, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXII; 119530L (2022) https://doi.org/10.1117/12.2610438
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Diffuse Reflectance Spectroscopy (DRS) uses light in the visible-near-infrared (NIR) spectrum for sub-surface sensing within optically turbid media such as biological tissues. Commonly, DRS based tissue sensing uses fiber-optic probes in direct contact with tissue, creating illumination and detection spots on the tissue sample at a fixed source-detector separation (SDS). Such a geometry eliminates Fresnel reflections from being collected by the detector and only samples multiply back-scattered light from the medium. Although fibers provide a straightforward means to implement DRS, physical contact of the fiber with tissue may perturb optical properties and, in several cases, may not be feasible. Here, we develop a non-contact, broadband optical system to acquire DRS measurements from a flat medium at a working distance of 2-3 cm. We characterize the beam profiles and geometry of our system and investigate the impact of varying working distance. Preliminary results show that the non-contact DRS system detects signatures of oxygenated hemoglobin in DRS measurements from human tissue and was sensitive to changes in spectral absorption in phantoms.

Citation Download Citation

Bradley Clemson, Michael Mrsan, and Karthik Vishwanath "Development of a portable, non-contact diffuse reflectance system for tissue spectroscopy", Proc. SPIE 11953, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXII, 119530L (2 March 2022); https://doi.org/10.1117/12.2610438

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