Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands

Christine Massie; Keren Chen; Hani A. Awad; Andrew J. Berger

doi:10.1117/12.2608714

2 March 2022 Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands

Christine Massie, Keren Chen, Hani A. Awad, Andrew J. Berger

Author Affiliations +

Proceedings Volume 11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry; 1195704 (2022) https://doi.org/10.1117/12.2608714
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Raman spectroscopy is a non-invasive vibrational technique that yields the biochemical signature of bone, and this can be done transcutaneously using spatially offset Raman spectroscopy. The percentage of bone signal detected will increase with further source-detector offsets, but the overall signal will be decreased. In recent work, our work suggests that 3 mm is an optimal offset for detecting bone signal for phalanges and 5 mm for measuring metacarpals. The objective of this work is to create and validate a SORS instrument that collects offsets at 0, 3, and 6 mm offsets simultaneously. By conducting simulations with an optical design software, we were able to optimize the imaging throughput for each offset location. Preliminary data from a cadaver specimen suggests we collect good quality data from offsets 0, 3, and 6 mm from both metacarpals and phalanges. Future work will work on validating this instrument as a valid tool to perform bone quality assessment.

Conference Presentation

Citation Download Citation

Christine Massie, Keren Chen, Hani A. Awad, and Andrew J. Berger "Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands", Proc. SPIE 11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, 1195704 (2 March 2022); https://doi.org/10.1117/12.2608714

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