Real-time optical diagnosis of prostate cancer: a clinical study on fresh biopsy cores

Suse J. van Breugel; Liam Quinn; Hannah Holtkamp; Ariane Araquel-Laciamento; Satya Amirapu; Komal Srinivasa; Irene Low; Mary L. Christie; Michel K. Nieuwoudt; Morgan R. Pokorny; Ramya Nagarajan; M. Cather Simpson; Kamran Zargar-Shoshtari; Claude Aguergaray

doi:10.1117/12.2621085

24 May 2022 Real-time optical diagnosis of prostate cancer: a clinical study on fresh biopsy cores

Suse J. van Breugel, Liam Quinn, Hannah Holtkamp, Ariane Araquel-Laciamento, Satya Amirapu, Komal Srinivasa, Irene Low, Mary L. Christie, Michel K. Nieuwoudt, Morgan R. Pokorny, Ramya Nagarajan, M. Cather Simpson, Kamran Zargar-Shoshtari, Claude Aguergaray

Author Affiliations +

Proceedings Volume 12146, Clinical Biophotonics II; 1214606 (2022) https://doi.org/10.1117/12.2621085
Event: SPIE Photonics Europe, 2022, Strasbourg, France

Abstract

Prostate cancer is a significant healthcare problem in many western countries. In response to the current need for more accurate and less invasive real-time diagnosis systems, we are developing a thin optical probe that uses Raman spectroscopy to detect prostate cancer in vivo and in real-time. We present results from an ex vivo study on fresh biopsy cores seconds after collection. Findings show that our system can identify prostate cancer from benign tissue, as well as differentiate tissue with different Gleason patterns. We aim to apply this technique, in the near future, for real-time PCa identification during routine biopsy appointments.

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Suse J. van Breugel, Liam Quinn, Hannah Holtkamp, Ariane Araquel-Laciamento, Satya Amirapu, Komal Srinivasa, Irene Low, Mary L. Christie, Michel K. Nieuwoudt, Morgan R. Pokorny, Ramya Nagarajan, M. Cather Simpson, Kamran Zargar-Shoshtari, and Claude Aguergaray "Real-time optical diagnosis of prostate cancer: a clinical study on fresh biopsy cores", Proc. SPIE 12146, Clinical Biophotonics II, 1214606 (24 May 2022); https://doi.org/10.1117/12.2621085

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