Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy

Ryuji Asaoka; Hiroshi Kiyomatsu; Akihiro Jono; Masaki Takao; Takashi Katagiri; Yusuke Oshima

doi:10.1117/12.2650088

14 March 2023 Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy

Ryuji Asaoka, Hiroshi Kiyomatsu, Akihiro Jono, Masaki Takao, Takashi Katagiri, Yusuke Oshima

Proceedings Volume 12363, Multiscale Imaging and Spectroscopy IV; 1236309 (2023) https://doi.org/10.1117/12.2650088
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Osteoarthritis is the most common disease in articular cartilage. Raman spectroscopy is a promising tool for early detection of degenerative changes in cartilage matrix. In this study, surgically resected humeral heads of 14 patients were subjected to pathological analysis using Raman spectroscopy with principal component analysis and hierarchical clustering analysis. In the result, Raman spectral data of each specimen were divided into three major cluster reflecting the alteration in molecular composition of cartilage matrix. We also found histological characteristics in the cluster, suggesting that Raman spectrum is a biomarker to determine the condition of the cartilage tissue.

Citation Download Citation

Ryuji Asaoka, Hiroshi Kiyomatsu, Akihiro Jono, Masaki Takao, Takashi Katagiri, and Yusuke Oshima "Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy", Proc. SPIE 12363, Multiscale Imaging and Spectroscopy IV, 1236309 (14 March 2023); https://doi.org/10.1117/12.2650088

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available