Visible-light optical coherence microscopy for corneal imaging

Shanjida Khan; Kai Neuhaus; Omkar Thaware; Mini Aga; Alireza Karimi; Mary Kelley; Travis Redd; Ted Acott; Myeong Jin; David Huang; Yifan Jian

doi:10.1117/12.2652252

8 March 2023 Visible-light optical coherence microscopy for corneal imaging

Shanjida Khan, Kai Neuhaus, Omkar Thaware, Mini Aga, Alireza Karimi, Mary Kelley, Travis Redd, Ted Acott, Myeong Jin, David Huang, Yifan Jian

Author Affiliations +

Proceedings Volume 12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; 123670K (2023) https://doi.org/10.1117/12.2652252
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Corneal disease is the fifth leading cause of global blindless. Optical coherence tomography (OCT) for anterior imaging is extensively used due to its non-invasive and high-resolution volumetric imaging characteristics. Optical coherence microscopy (OCM) is a technical variation of OCT that can image the cornea with cellular resolution. Here, we demonstrate a visible-light OCM as a low-cost and easily reproducible system to visualize various corneal cellular structures such as epithelial cells, endothelial cells, keratocytes, and collagen bundles within stromal lamellae. The visible-light OCM was also used to study pressure changes in anterior segment human donor eyes. The system achieved an axial resolution of 12 μm in tissue over a 1.2 mm imaging depth, and a lateral resolution of 1.6 µm over a field of view of up to 750 μm × 750 μm.

Conference Presentation

Citation Download Citation

Shanjida Khan, Kai Neuhaus, Omkar Thaware, Mini Aga, Alireza Karimi, Mary Kelley, Travis Redd, Ted Acott, Myeong Jin, David Huang, and Yifan Jian "Visible-light optical coherence microscopy for corneal imaging", Proc. SPIE 12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, 123670K (8 March 2023); https://doi.org/10.1117/12.2652252

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