Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate

Sazgar Burhan; Nicolas Detrez; Katharina Rewerts; Madita Göb; Christian Hagel; Matteo Mario Bonsanto; Dirk Theisen-Kunde; Robert Huber; Ralf Brinkmann

doi:10.1117/12.2648301

6 March 2023 Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate

Sazgar Burhan, Nicolas Detrez, Katharina Rewerts, Madita Göb, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

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Proceedings Volume 12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI; 123680F (2023) https://doi.org/10.1117/12.2648301
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Optical coherence elastography (OCE) offers the possibility of obtaining the mechanical behavior of a tissue. When also using a non-contact mechanical excitation, it mimics palpation without interobserver variability. One of the most frequently used techniques is phase-sensitive OCE. Depending on the system, depth-resolved changes in the sub-µm to nm range can be detected and visualized volumetrically. Such an approach is used in this work to investigate and detect transitions between healthy and tumorous brain tissue as well as inhomogeneities in the tumor itself to assist the operating surgeon during tumor resection in the future. We present time-resolved, phase-sensitive OCE measurements on various ex vivo brain tumor samples using an ultra-fast 3.2 MHz swept-source optical coherence tomography (SS-OCT) system with a frame rate of 2.45 kHz. 4 mm line scans are acquired which, in combination with the high imaging speed, allow monitoring and investigation of the sample's behavior in response to the mechanical load. Therefore, an air-jet system applies a 200 ms short air pulse to the sample, whose non-contact property facilitates the possibility for future in vivo measurements. Since we can temporally resolve the response of the sample over the entire acquisition time, the mechanical properties are evaluated at different time points with depth resolution. This is done by unwrapping the phase data and performing subsequent assessment. Systematic ex vivo brain tumor measurements were conducted and visualized as distribution maps. The study outcomes are supported by histological analyses and examined in detail.

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Sazgar Burhan, Nicolas Detrez, Katharina Rewerts, Madita Göb, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, and Ralf Brinkmann "Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate", Proc. SPIE 12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, 123680F (6 March 2023); https://doi.org/10.1117/12.2648301

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