Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy

Ola Abdalsalam; Nicholas A. Ross; Guy A. Perkins; Robin Dale; Hamid Dehghani; Thomas D. O'Sullivan; Silvina L. Ferradal

doi:10.1117/12.2650970

7 March 2023 Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy

Ola Abdalsalam, Nicholas A. Ross, Guy A. Perkins, Robin Dale, Hamid Dehghani, Thomas D. O'Sullivan, Silvina L. Ferradal

Proceedings Volume 12376, Optical Tomography and Spectroscopy of Tissue XV; 1237607 (2023) https://doi.org/10.1117/12.2650970
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Frequency-domain near-infrared spectroscopy (FD-NIRS) can measure absolute tissue optical properties for functional brain imaging. Multiple source-detector separations (SDS), and multiple modulation frequencies can be used for FD-NIRS application in homogeneous or multi-layer tissue models. A multiple-frequency approach is advantageous in building more compact systems with a single SDS. In this work, we compare the accuracy of estimating absolute optical properties of a multi-layered tissue model using multi-distance and multi-frequency approaches. We demonstrate that the multiple-frequency approach is comparable in accuracy to the multiple-distance approach and can be confidently implemented for brain imaging applications.

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Citation Download Citation

Ola Abdalsalam, Nicholas A. Ross, Guy A. Perkins, Robin Dale, Hamid Dehghani, Thomas D. O'Sullivan, and Silvina L. Ferradal "Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy", Proc. SPIE 12376, Optical Tomography and Spectroscopy of Tissue XV, 1237607 (7 March 2023); https://doi.org/10.1117/12.2650970

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