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16 March 2023 Handheld quantitative phase imaging probe for in-vivo brain tumor margin assessment
Zhe Guang, Paloma Casteleiro Costa, Amunet Jacobs, Caroline Filan, Francisco E. Robles
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Proceedings Volume 12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; 123910C (2023) https://doi.org/10.1117/12.2650851
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Quantitative phase imaging (QPI) enables label-free optical-path-length measurement of biological samples with nanometer-scale sensitivity, which offers unparalleled access to important histological and biophysical properties of cells and tissues. However, traditional QPI methods require a transmission-based optical geometry and are thus restricted to thin samples, which prevents the use of QPI for in-vivo applications. In this work, we present the design, characterization, and experimental validation of a handheld rigid probe for QPI with epi-illumination, using an optimized lighting configuration to achieve high phase-contrast sensitivity. The approach is based on a recently developed technology called quantitative oblique back illumination microscopy (qOBM). We demonstrate the real-time operation of our system with the future goal of applying it to help guide human brain tumor margin assessment intraoperatively in vivo, among many other potential applications.
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Zhe Guang, Paloma Casteleiro Costa, Amunet Jacobs, Caroline Filan, and Francisco E. Robles "Handheld quantitative phase imaging probe for in-vivo brain tumor margin assessment", Proc. SPIE 12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, 123910C (16 March 2023); https://doi.org/10.1117/12.2650851
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KEYWORDS
Tumors
Brain
In vivo imaging
Phase imaging
Biological samples
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