Regulation and therapeutic applications of autophagy in cancer

Yingting Jiang

doi:10.1117/12.2692769

7 September 2023 Regulation and therapeutic applications of autophagy in cancer

Yingting Jiang

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127891B (2023) https://doi.org/10.1117/12.2692769
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Autophagy is a cell death mechanism that involves the destruction of substances within an organism's cells in response to several external stresses. A double-membrane structure of autophagosomes transports degradable components, including damaged organelles and misfolded proteins, to lysosomes for breakdown and recycling. With the development of technology, there is accumulating evidence that autophagy is associated with a variety of human disorders, including cancer. During the progression from benign to malignant cancer, autophagy suppresses cancer cells while boosting the growth and spread of cancerous tumor cells. In conclusion, the exploitation of autophagy as a prospective target for the treatment of cancer is becoming an increasingly popular avenue for researchers. This study has reviewed the regulatory processes of autophagy in cancer, the double role of autophagy in cancer, and the therapeutic applications of autophagy in cancer based on the underlying mechanisms of autophagy in cancer for pancreatic cancer, breast cancer, and how existing drugs can inhibit tumor progression.

Citation Download Citation

Yingting Jiang "Regulation and therapeutic applications of autophagy in cancer", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127891B (7 September 2023); https://doi.org/10.1117/12.2692769

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