Regulation of energy metabolism by eEF2K in tumor cells

Jiachai Wang

doi:10.1117/12.2692913

7 September 2023 Regulation of energy metabolism by eEF2K in tumor cells

Jiachai Wang

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127891F (2023) https://doi.org/10.1117/12.2692913
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Metabolic reprogramming is one of the primary characteristics of tumor cells. Aerobic glycolysis is the primary mechanism by which tumor cells and normal cells differ in their glucose metabolism. The Ca2+/CAM-dependent protein kinase known as eukaryotic elongation factor 2 kinase (eEF2K) is significantly activated in various tumor cells and is involved in the control of tumor cell survival, proliferation, invasion and metastasis. For example, it acts as a protein synthesis regulator to mediate the process of protein synthesis in tumor cells under nutrient deprivation conditions. This paper describes the main regulatory mechanism of eEF2K and three pathways that affect eEF2K. In recent years, various studies have shown that eEF2K has very different or even opposite effects in different tumor cells. Therefore, clarifying the role and mechanism of eEF2K in different tumors is of great significance for drug research and development, and eEF2K is a potential therapeutic target for the development of anticancer drugs.

Citation Download Citation

Jiachai Wang "Regulation of energy metabolism by eEF2K in tumor cells", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127891F (7 September 2023); https://doi.org/10.1117/12.2692913

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Cancer

Glucose

Mode conditioning cables

Neodymium

Proteins

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