Cluster synchronization in fractional-order dynamic dementia networks

A. Meyer-Baese; K. Mueller; Hae Sol Moon; G. Nagamani; U. Meyer-Baese; D. A. Bistrian; A. Stadlbauer; H. Malberg

doi:10.1117/12.3008247

2 April 2024 Cluster synchronization in fractional-order dynamic dementia networks

A. Meyer-Baese, K. Mueller, Hae Sol Moon, G. Nagamani, U. Meyer-Baese, D. A. Bistrian, A. Stadlbauer, H. Malberg

Proceedings Volume 12930, Medical Imaging 2024: Clinical and Biomedical Imaging; 129302L (2024) https://doi.org/10.1117/12.3008247
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Conference Poster

Abstract

Brain networks can be naturally divided into clusters or communities where the cluster’s nodes dynamics have similar trajectories in phase space. This process is known as synchronization, and represents characteristics of intragroup features and not between groups. Fractional calculus represents a generalization of ordinary differentiation and integration to arbitrary non-integer order, and can be thought of as a smooth interpolation between different orders of differentiation/integration, providing the ability to probe the system from many different viewpoints of the dynamics. Fractional calculus has been explored as an excellent tool for the description of memory in many processes and may be more accurate for modeling brain processes than traditional integer-order ones. We apply the concept of cluster synchronization in fractional-order structural brain networks ranging from healthy controls to Alzheimer’s disease subjects and determine whether cluster synchronization can be achieved in these networks. We observe the existence of a hypersynchronization only in AD structural networks and consider that this could represent an excellent non-invasive biomarker for tracking the disease evolution and decide upon therapeutic interventions.

Citation Download Citation

A. Meyer-Baese, K. Mueller, Hae Sol Moon, G. Nagamani, U. Meyer-Baese, D. A. Bistrian, A. Stadlbauer, and H. Malberg "Cluster synchronization in fractional-order dynamic dementia networks", Proc. SPIE 12930, Medical Imaging 2024: Clinical and Biomedical Imaging, 129302L (2 April 2024); https://doi.org/10.1117/12.3008247

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