Laser-assisted detection of endogenous porphyrins in malignant diseases

Ronald Sroka; Reinhold Baumgartner; A. Buser; Christian Ell; Dieter Jocham; Eberhard Unsoeld

doi:10.1117/12.59353

6 May 1992 Laser-assisted detection of endogenous porphyrins in malignant diseases

Ronald Sroka, Reinhold Baumgartner, A. Buser, Christian Ell, Dieter Jocham, Eberhard Unsoeld

Proceedings Volume 1641, Physiological Monitoring and Early Detection Diagnostic Methods; (1992) https://doi.org/10.1117/12.59353
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Visualization of earlystagecancer turnsout to be a keypoint in dinical oncology. Ruorescence detection of systemicallyadministered dyes provento accumulate in tumors is one type of diagnostic procedure. The occurrence of endogenous chromophores in malignant tissue has been observed through laserinduced fluorescence in the red spectral range between 550nm and 750nm. Following lumination aftemating between violet and blue lines from a Kr-laser, an optkal mu1tkhanne1 analyser has detected fluorescence in defined areas wfthin chemically induced bladder tumors in rats. The same technique has also been used for the quantitative comparison of fluorescence in human gastrointestinal tumors in nude mice in-vivo. Results show that endogenous porphynns are present in rat bladder tumors as well as in gastrointestinal tumors in nude mice. A correlation between the porphyrin-related fluorescence signal and the histopathological examination indicates that the porphyrin content is dependent upon the tumor grading.

Citation Download Citation

Ronald Sroka, Reinhold Baumgartner, A. Buser, Christian Ell, Dieter Jocham, and Eberhard Unsoeld "Laser-assisted detection of endogenous porphyrins in malignant diseases", Proc. SPIE 1641, Physiological Monitoring and Early Detection Diagnostic Methods, (6 May 1992); https://doi.org/10.1117/12.59353

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available