Laser desorption in an ion-trap mass spectrometer

Gregory C. Eiden; M. E. Cisper; Michael A. Alexander; P. H. Hemberger; Nicholas S. Nogar

doi:10.1117/12.148520

2 July 1993 Laser desorption in an ion-trap mass spectrometer

Gregory C. Eiden, M. E. Cisper, Michael A. Alexander, P. H. Hemberger, Nicholas S. Nogar

Proceedings Volume 1857, Lasers and Optics for Surface Analysis; (1993) https://doi.org/10.1117/12.148520
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Laser desorption in an ion-trap mass spectrometer shows significant promise for both qualitative and trace analysis. Several aspects of this methodology are discussed in this work. We previously demonstrated the generation of both negative and positive ions by laser desorption directly within a quadrupole ion trap. In the present work, we explore various combinations of dc, rf, and time-varying fields in order to optimize laser generated signals. In addition, we report on the application of this method to analyze samples containing compounds such as amines, metal complexes, carbon clusters, and polyaromatic hydrocarbons (PAHs). In some cases the ability to rapidly switch between positive and negative ion modes provides sufficient specificity to distinguish different compounds of a mixture with a single stage of mass spectrometry. In other experiments, we combined intensity variation studies with tandem mass spectrometry experiments and positive and negative ion detection to further enhance specificity.

Citation Download Citation

Gregory C. Eiden, M. E. Cisper, Michael A. Alexander, P. H. Hemberger, and Nicholas S. Nogar "Laser desorption in an ion-trap mass spectrometer", Proc. SPIE 1857, Lasers and Optics for Surface Analysis, (2 July 1993); https://doi.org/10.1117/12.148520

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