Photodynamic therapy of port wine stain: preliminary clinical studies

J. Stuart Nelson M.D.

doi:10.1117/12.147022

1 July 1993 Photodynamic therapy of port wine stain: preliminary clinical studies

J. Stuart Nelson M.D.

Proceedings Volume 1876, Lasers in Otolaryngology, Dermatology, and Tissue Welding; (1993) https://doi.org/10.1117/12.147022
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The broad, long term objective of this work is the development of Photodynamic Therapy (PDT) for application in the clinical management of patients with port wine stain (PWS). PDT involves the use of an exogenous drug which is concentrated in a targeted tissue. When irradiated at wavelengths specifically absorbed by the drug, selective destruction of the targeted tissue, without the production of heat, occurs. The results of this preliminary study demonstrate in human PWS patients that a photosensitizer, such as PHOTOFRIN^R, activated by red light at the appropriate therapeutic wavelength, can cause destruction of subsurface blood vessels in the skin with a high degree of specificity, and further study appears warranted.

Citation Download Citation

J. Stuart Nelson M.D. "Photodynamic therapy of port wine stain: preliminary clinical studies", Proc. SPIE 1876, Lasers in Otolaryngology, Dermatology, and Tissue Welding, (1 July 1993); https://doi.org/10.1117/12.147022

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