Diagnostic potentials of laser nephelometry of aggregating erythrocytes suspension

Nikolai N. Firsov; Alexander V. Priezzhev; Olga M. Ryaboshapka; Igor V. Sirko

doi:10.1117/12.146191

17 June 1993 Diagnostic potentials of laser nephelometry of aggregating erythrocytes suspension

Nikolai N. Firsov, Alexander V. Priezzhev, Olga M. Ryaboshapka, Igor V. Sirko

Proceedings Volume 1922, Laser Study of Macroscopic Biosystems; (1993) https://doi.org/10.1117/12.146191
Event: Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, 1992, Jyvaskyla, Finland

Abstract

The viscous properties of blood are of major importance for circulation in vessels with diameters less than 100 mm. The disturbance of microcirculation is observed in many pathologies. The blood viscosity under low shear rates is determined by the aggregation ability of erythrocytes. So, an important problem of hemorheology is the determination of the durability of aggregates, their sizes, and the aggregation kinetics. To measure these parameters the nephelometric technique is widely applied in different modifications enabling the registration of the backscattered or the transmitted light intensity. We present here the results of our study of peculiarities of the (dis)aggregation kinetics in relation to different pathologies: psoriatic arthritis, inherited hypercholesteremia, inherited homoglobinopathy, and some others. These results show the high diagnostic potentials of laser nephelometric technique.

Citation Download Citation

Nikolai N. Firsov, Alexander V. Priezzhev, Olga M. Ryaboshapka, and Igor V. Sirko "Diagnostic potentials of laser nephelometry of aggregating erythrocytes suspension", Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); https://doi.org/10.1117/12.146191

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